Transforming Growth Factor-Beta1 in Diabetic Kidney Disease
نویسندگان
چکیده
منابع مشابه
The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.
All three isoforms of transforming growth factors beta (TGF-betal, TGF-beta2, and TGF-beta3) are secreted as latent complexes and activated extracellularly, leading to the release of the mature cytokines from their noncovalently associated proregions, also known as latency-associated peptides (LAPs). The LAP region of TGF-beta1 was expressed in a baculovirus expression system and purified to ho...
متن کاملLovastatin inhibits transforming growth factor-beta1 expression in diabetic rat glomeruli and cultured rat mesangial cells.
Diabetic nephropathy is a leading cause of end-stage renal disease and is characterized by excessive deposition of extracellular matrix (ECM) proteins in the glomeruli. Transforming growth factor-beta (TGF-beta) is the major mediator of excessive accumulation of ECM proteins in diabetic nephropathy through upregulation of genes encoding ECM proteins as well as downregulation of genes for ECM-de...
متن کاملMyofibroblasts and Transforming Growth Factor-Beta1 in Reactive Gingival Overgrowths
OBJECTIVES The purpose of this study was to evaluate the oral health-related quality of life of patients treated with implant-supported mandibular overdentures and to compare the attachment systems used. MATERIAL AND METHODS The presence of myofibroblasts as well as transforming growth factor-beta1 was examined in twenty cases of fibrous epulis and 22 ossifying fibrous epulis, using immunohis...
متن کاملIncreased Transforming Growth Factor-beta1 in Alcohol Dependence
Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-beta1) expression in animal studies. TGF-beta1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-beta1 levels measured by ELISA were compare...
متن کاملCirculating transforming growth factor-beta1 levels in asymptomatic carotid plaques.
Circulating Transforming Growth Factor1 Levels in Asymptomatic Carotid Plaques To the Editor: It was with great interest we read the report by Cipollone et al1 on the role of transforming growth factor1 (TGF1) in the process of plaque stabilization. The authors demonstrate that TGFmRNA levels are increased up to 3-fold in asymptomatic as compared with symptomatic plaques, with a parallel increa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2020
ISSN: 2296-634X
DOI: 10.3389/fcell.2020.00187